For some reason, my Cobra 75 (all-in-one) works great, knock on wood.
I don't get any fuel pump noise (lucky, I know), just from the wipers, turn signals (odd, I know), and some other interior electronics. But then again, my cb is powered from the internal fuse block, I know, I'm lazy.
My VHF is direct from battery, and runs flawless, though there is some QRM/QRN picked up by the cb, when the VHF PTT is triggered when the radio is in ultra-high-power tx, 75w.
I do have to do some maint, check grounds, SWR, connector corrosion, etc. So I just might be in that zone of "if it ain't broken, don't touch it!"
I do plan on running my radio's off and direct power bus, power-poles or similar. But put noise filters on both the + and - leads for each radio.
It's not a perfect world, and sometimes we just have to deal with imperfections, and with radio, we deal with it the minute we turn the unit on!